The Church of God in the Southern Region in Africa is in most places known as Full Gospel Church of God, as it has its roots in the amalgamation agreement in 1954 between the Church of God in Cleveland TN and the Full Gospel Church in South Africa.

Those countries under CoG Africa Southern region are: Botswana, Lesotho, Madagascar, Mauritius, Mozambique (FGCoG), Namibia, Reunion, Swaziland and Zimbabwe. The region under the leadership of the Regional Superintendent also works in relationship with the Full Gospel Church Of God in South Africa with its HQ in Irene.